Its Computational Science & Engineering division works to solve scientific and engineering problems via modeling, simulation and data analysis, observation, and experimentation. Its complementary research center, Center for Experimental Research in Computing Systems (CERCS), researches design and evaluation of complex computer and software systems through experimental methods.

One of CERCS' leading projects is the Interactive High-Performance Computing (IHPC) Lab, drawing funding from NSF grants and actively-engaged private industry partners including Intel, Dell and Cisco.

University of Hawaii - MHPCC
The Maui High Performance Computing Center (MHPCC) is an Air Force Research Laboratory Center managed by the University of Hawaii. MHPCC is an Allocated Distributed Center of the Department of Defense High Performance Computing Modernization Program, providing more than 10,000,000 hours of computing time per year to the research, science, and warfighter communities. C's terascale, High Performance Computing resources showcase a wide range of technologies, which include a Cray XD1 with AMD Opteron. processors, IBM Power3 and Power4 configurations, and large Linux clusters. MHPCC is a national resource chartered to support a diverse base of DoD and other government users, facilitating the collaborations needed to solve today's complex computational problems.